[Objective] Lithium-ion batteries are widely used in new energy transportation and power systems, which pose significant risks during experimentation. The risks include thermal runaway, leakage, smoke, fire, explosion, and toxic gas release. This paper explored the application of intelligent technologies of safety management in lithium-ion battery laboratories, which was focused on enhancing safety and preventing accidents. A comprehensive safety management system was developed, which integrated wireless communication, radio frequency identification (RFID) technology, sensors, and actuators to ensure safe laboratory operations. [Methods] To achieve previous objectives, this paper adopted a multifaceted approach to manage lithium-ion battery safety in laboratories. It started by examining the current state of laboratory safety and the importance of implementing advanced safety measures. The authors then discussed the characteristics of lithium-ion batteries, including the potential dangers associated with their use and storage. Shortcomings of traditional safety measures were analyzed and the paper highlighted the need for automation, informatization, and digitization in safety management. The paper explored the application of wireless communication technologies, such as Wi-Fi, Bluetooth, Zigbee, LoRa, and NB-IoT, which could offer reliable performance, cost-effectiveness, and low installation costs. RFID technology was utilized for inventory management and personal protective equipment (PPE) monitoring. Sensors were installed to detect hazardous conditions, and actuators were employed to mitigate risks automatically. The integration of these technologies aimed to create a smart safety management system that would cover all aspects of laboratory operations, from inventory control and PPE monitoring to experimental processes. [Results] The implementation of intelligent safety management technologies had resulted in significant improvements in laboratory safety. By automating safety protocols, the system reduced the likelihood of human error and enhances response times to potential hazards. For instance, sensors could detect early signs of thermal runaway, allowing immediate action to prevent accidents. RFID technology ensured that PPE was properly maintained and readily available, while wireless communication technologies enabled real-time monitoring and control of experimental conditions. The integration of these technologies had led to a safer working environment, reduced accident rates, and more efficient management of lithium-ion battery experiments. The paper demonstrated the effectiveness of these technologies in mitigating risks associated with lithium-ion batteries and provided guidelines for their implementation in laboratories. [Conclusion] The study concluded that the integration of intelligent safety management technologies significantly improved the safety of lithium-ion battery laboratories. Wireless communication, RFID, sensors, and actuators played critical roles in creating a comprehensive safety management system that covers all aspects of laboratory operations. The adoption of these technologies not only enhanced safety but also streamlined processes and reduced the risk of accidents. The findings underscored the importance of adopting advanced safety measures in laboratories to protect personnel and ensured the integrity of research. Future research should continue to explore innovative ways to integrate these technologies and further enhance laboratory safety.